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We quantitated the concentrations of prostatic acid phosphatases (EC 3.1.3.2) in serum and bone-marrow aspirates with three commercial radioimmunoassay kits, and the catalytic activities with a thymolphthalein monophosphate-based enzyme test. The enzyme's immunological activity in serum was compared with its catalytic activity for its potential as a detector of early prostatic cancer and its performance as an early marker of metastatic activity in bone. Neither measurement is useful for detecting early stages of prostatic cancer. The spread of carcinoma to lymph nodes or to bone is detected with greater frequency by radioimmunoassay than by the enzymic test. Radioimmunoassay also detected metastasis to the bone more frequently than did physical methods. Analytical and clinical performance of the four methods is described.
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
January 1982,
Urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
January 1980,
The Prostate,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
April 1979,
The Journal of urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
March 1978,
The Journal of urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
September 1978,
British medical journal,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
April 1982,
Urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
October 1974,
Urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
January 1983,
Urology,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
June 1978,
New York state journal of medicine,
P R Huber, and
A Scholer, and
E Linder, and
V Hagmaier, and
H Vogt, and
P Christen, and
U Eppenberger, and
G Rutishauser
June 1978,
Cancer,
