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The present experiments examined some characteristics of the enhanced striatal [3H]ADTN binding which occurs following substantia nigra lesion. The amount of binding of a fixed concentration of [3H]ADTN was greatly increased. The amount of guanine nucleotide sensitivity increased to an even greater extent than total [3H]ADTN binding. Saturation experiments showed one component of [3H]ADTN binding (KD 7 nM) in intact striata whereas there were two components of binding (KD 9 nM and KD 1 nM) in substantia nigra-lesioned striata. Most of the enhanced binding in substantia nigra-lesioned striata was the higher affinity component. Kainic acid lesion of substantia nigra-lesioned striata caused loss of the enhanced [3H]ADTN binding and the high affinity component of [3H]ADTN binding. These results indicate that following dopaminergic denervation, either the binding characteristics of a single type of dopamine receptor are altered or there is a specific increase in a distinct subtype of dopamine receptor with high agonist affinity and sensitivity to guanine nucleotides.
I D Hirschhorn, and
M H Makman
April 1982,
Biochemical pharmacology,
I D Hirschhorn, and
M H Makman
January 1988,
Life sciences,
I D Hirschhorn, and
M H Makman
October 2004,
Brain research,
I D Hirschhorn, and
M H Makman
March 2018,
Internal medicine (Tokyo, Japan),
I D Hirschhorn, and
M H Makman
August 1994,
Proceedings of the National Academy of Sciences of the United States of America,
I D Hirschhorn, and
M H Makman
May 1980,
Neuroscience letters,
I D Hirschhorn, and
M H Makman
October 1988,
Brain research,
I D Hirschhorn, and
M H Makman
March 1993,
Neuroscience,
I D Hirschhorn, and
M H Makman
June 1986,
Neuroscience letters,
I D Hirschhorn, and
M H Makman
June 1983,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
