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The in vivo effect of Nocardia rubra cell-wall skeleton (N-CWS) was studies on the generation of bone marrow granulocyte-macrophage progenitor cells [colony-forming units culture (CFU-c)] and on the levels of myeloid colony-stimulating activity (CSA) in the conditioned medium of the lung (LCM) and serum obtained from mice. In vitro bone marrow culture showed that intraperitoneal (ip) treatment of mice with N-CWS markedly enhanced CFU-c formation induced by stimuli in LCM or serum derived from lipopolysaccharide (LPS)-treated mice. The LCM and serum of mice injected with N-CWS ip were also prepared and assayed for CSA. CSA levels with N-CWS-LCM as well as LPS-LCM used as the standard CSA were markedly greater than those achieved with control LCM. N-CWS-serum also showed a low but significant level of CSA. The CSA level of N-CWS-LCM was maximal at 3 to 5 days after N-CWS injection. These results raise the possibility that enhanced CSA production might be a major mechanism for N-CWS stimulation of granulocyte-macrophage production.
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
April 1986,
Infection and immunity,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
January 1992,
Cancer immunology, immunotherapy : CII,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
April 1986,
Cancer research,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
August 1991,
Cancer research,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
February 1982,
Arerugi = [Allergy],
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
October 1978,
Gan,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
January 1981,
Cancer treatment reports,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
April 1983,
Nihon Geka Gakkai zasshi,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
January 1988,
International journal of immunopharmacology,
M Ito, and
H Suzuki, and
N Nakano, and
N Yamashita, and
M Sugimori, and
E Sugiyama, and
M Maruyama, and
Y Asanuma, and
S Yano
March 1980,
European journal of cancer,
