-transparent.png){kind=logo}
Neoplastic transformation of rabbit cells by Kirsten murine sarcoma virus (Ki-MSV), the Ki-MSV pseudotype of baboon endogenous virus (Ki-MSV[BaEV]) and the Moloney-MSV pseudotype of feline leukemia virus (M-MSV[FeLV]) is reported. Rabbit cells can be readily transformed by Ki-MSV, Ki-MSV(BaEV) and M-MSV(FeLV). Rabbit cells transformed by Ki-MSV and M-MSV(FeLV) were found to be virus producers, whereas those transformed by Ki-MSV(BaEV) were nonproducers (NP). The NP cells were obtained by simply infection rabbit cells with Ki-MSV(BaEV) and subculturing the infected cells. Although the morphologically altered NP cells did not produce infectious virus or murine leukemia virus antigen, they did contain a rescuable MSV genome. All of the transformed cells formed colonies in soft agar, grew to high saturation densities and produced tumors when transplanted into nude mice. The Ki-MSV and M-MSV(FeLV)-transformed cells produced tumors in newborn WH/J rabbits, thus providing an important tool for studying tumor immunity in the rabbit.
J S Rhim, and
H G Bedigian, and
R R Fox
January 1975,
Bibliotheca haematologica,
J S Rhim, and
H G Bedigian, and
R R Fox
June 1978,
Gan,
J S Rhim, and
H G Bedigian, and
R R Fox
January 1970,
Nature,
J S Rhim, and
H G Bedigian, and
R R Fox
January 1988,
Journal of cellular physiology,
J S Rhim, and
H G Bedigian, and
R R Fox
February 1980,
The Japanese journal of experimental medicine,
J S Rhim, and
H G Bedigian, and
R R Fox
April 1985,
Molecular and cellular biology,
J S Rhim, and
H G Bedigian, and
R R Fox
July 1982,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J S Rhim, and
H G Bedigian, and
R R Fox
September 1976,
Cancer research,
J S Rhim, and
H G Bedigian, and
R R Fox
November 1980,
Nature,
J S Rhim, and
H G Bedigian, and
R R Fox
March 1985,
Science (New York, N.Y.),
