Biomaterial Database

Distribution and retention of 239Pu in the tree shrew (Tupaia belangeri) following intramuscular injection. 1982

A Seidel, and G Darai, and R Flügel, and W Hofmann, and W Sontag

The retention of intramuscularly injected monomeric 239Pu has been studied in the tree shrew (Tupaia belangeri), a primitive prosimian species. Data for the first 2 yr are presented. Resorption from the injection site is rapid, and the main depository organs are skeleton and liver with approximately 50 and 20% of the absorbed dose, respectively. The half life of retention in skeleton is approximately 500-600 days and in liver approximately 150 days, these half lives are compared to data for the retention of transuranium elements in other animal species. Indications of liver lesions were found in 5 animals and 1 animal died at day 790 with an osteosarcoma.

UI	MeSH Term	Description	Entries
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011005	Plutonium	A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, and atomic number 94. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D014418	Tupaiidae	The only family of the order SCANDENTIA, variously included in the order Insectivora or in the order Primates, and often in the order Microscelidea, consisting of five genera. They are TUPAIA, Ananthana (Indian tree shrew), Dendrogale (small smooth-tailed tree shrew), Urogale (Mindanao tree shrew), and Ptilocercus (pen-tailed tree shrew). The tree shrews inhabit the forest areas of eastern Asia from India and southwestern China to Borneo and the Philippines.	Ptilocercus,Shrews, Tree,Tree Shrews,Tupaiinae,Treeshrews,Shrew, Tree,Tree Shrew,Treeshrew