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Normal adult men with long and short phenytoin plasma half-lives were given 300-mg oral doses of phenytoin once daily for 15 days. Plasma levels of phenytoin (DPH) and its major metabolite (p-HPPH) were measured during the period of drug administration and for 5 days thereafter. Average steady-state plasma levels of DPH rose to 13.4 micrograms/ml in the long half-life group, compared with 3.6 micrograms/ml in the short half-life group. HPPH levels in the long half-life group were about one half of those observed in the short half-life group. The DPH/HPPH ratios in plasma specimens showed excellent correlation with the plasma half-lives of DPH and average steady-state levels, suggesting that this ratio could provide guidance in the selection of optimum dosage regimens for problem patients.
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
September 1948,
Nucleonics,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
May 2015,
Anesthesiology,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
July 1985,
British medical journal (Clinical research ed.),
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
January 1973,
Pharmacology,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
August 1993,
Clinical pharmacology and therapeutics,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
February 1988,
Lancet (London, England),
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
March 1988,
Lancet (London, England),
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
January 1983,
European journal of clinical pharmacology,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
February 2010,
International journal of antimicrobial agents,
A J Glazko, and
F E Peterson, and
T Chang, and
W A Dill, and
T C Smith, and
R A Buchanan
July 1998,
Biological psychiatry,
