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The free tetraiodothyronine index (FT4I) and free triiodothyronine index (FT3I) in burn patients represented the serum levels of free (dialyzable) T4 and free T3, respectively. FT4I and FT3I were lower with greater burn size and were lower in nonsurvivors than expected for the burn size. there was no compensatory elevation of basal or releasing hormone-stimulated thyrotrophin (TSH) concentrations. Reverse T3 was higher with greater burn size. T3 treatment restored FT3I but did not affect mortality or resting metabolic rate (MR) measured in survivors, compared with placebo therapy. Whereas the hypermetabolic response to burn injury appeared t be independent of thyroid hormones, MR was correlated positively with burn size and with elevated plasma norepinephrine and epinephrine concentrations for several weeks after injury. Lack of augmented TSH concentrations, absence of low plasma reverse T3, and presence of hypermetabolism suggest that the reduced plasma free T3 does not indicate functional hypothyroidism, but may represent an adaptation to the assumption of metabolic control by the sympathetic nervous system.
R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
December 1990,
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R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
May 1992,
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R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
October 2009,
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R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
November 1985,
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R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
April 1973,
Archives of surgery (Chicago, Ill. : 1960),
R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
May 2020,
Burns : journal of the International Society for Burn Injuries,
R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
July 1980,
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R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
January 1960,
Biochemische Zeitschrift,
R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
January 2003,
Nestle Nutrition workshop series. Clinical & performance programme,
R A Becker, and
G M Vaughan, and
M G Ziegler, and
L G Seraile, and
I W Goldfarb, and
E H Mansour, and
W F McManus, and
B A Pruitt, and
A D Mason
March 2002,
Journal of wound care,
