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A peptide isolated from porcine gut according to its glucagon-like activity in liver (bioactive enteroglucagon) has been characterized immunologically, biologically and chemically: its potency relative to pancreatic glucagon in interacting with an antiglucagon antibody, hepatic glucagon-binding sites and hepatic adenylate cyclase was approximately 100%, 20% and 10%, respectively. In contrast, it is approximately 20-times more potent than glucagon in oxyntic glands, justifying the term 'oxyntomodulin'. Chemically, it consists in the 29 amino acid-peptide glucagon elongated at its C-terminal end by the octapeptide Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala; accordingly, it is called 'glucagon-37'.
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
September 1982,
FEBS letters,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
January 1984,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
June 1982,
Bioscience reports,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
July 1984,
Endocrinology,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
January 1975,
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
January 1988,
General and comparative endocrinology,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
August 1985,
Regulatory peptides,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
January 1987,
Peptides,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
October 1984,
Endocrinology,
D Bataille, and
K Tatemoto, and
C Gespach, and
H Jörnvall, and
G Rosselin, and
V Mutt
January 1984,
Peptides,
