-transparent.png){kind=logo}
The pharmacokinetics of amoxicillin was investigated in 4 healthy volunteers and in 16 patients with varying degrees of renal impairment, 4 of whom were on regular hemodialysis. Amoxicillin was administered both in a 1-g single intravenous injection and two 500-mg capsules per os. The kinetics of the antibiotic followed an open two-compartment model. In the patients with renal failure there was a significant decrease in beta, kappa10, and total body clearance. A linear relationship between beta of amoxicillin and creatinine clearance was found. This relationship allows dosage regimen adjustment for patients with renal impairment. A significant increase in the absorption half-life of the antibiotic was also observed in patients with renal impairment. The half-life of the antibiotic during hemodialysis was 2.3 h.
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
January 1990,
Antimicrobial agents and chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
November 1991,
Antimicrobial agents and chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
October 1980,
European journal of clinical pharmacology,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
March 1980,
Antimicrobial agents and chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
September 1980,
The Journal of antimicrobial chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
March 2008,
Journal of clinical pharmacology,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
January 1978,
Antibiotics and chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
June 1981,
Antimicrobial agents and chemotherapy,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
November 1988,
Arzneimittel-Forschung,
A Arancibia, and
M T Drouguett, and
G Fuentes, and
G González, and
C González, and
S Thambo, and
G Palombo
January 2000,
British journal of clinical pharmacology,
