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A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.
E L Howes, and
D H Char, and
M Christensen
May 1979,
American journal of ophthalmology,
E L Howes, and
D H Char, and
M Christensen
November 1992,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
E L Howes, and
D H Char, and
M Christensen
September 1983,
Klinische Monatsblatter fur Augenheilkunde,
E L Howes, and
D H Char, and
M Christensen
January 1987,
Archivum immunologiae et therapiae experimentalis,
E L Howes, and
D H Char, and
M Christensen
January 1987,
Vestnik oftalmologii,
E L Howes, and
D H Char, and
M Christensen
July 1989,
International ophthalmology,
E L Howes, and
D H Char, and
M Christensen
September 1981,
Transactions of the ophthalmological societies of the United Kingdom,
E L Howes, and
D H Char, and
M Christensen
January 1989,
Klinika oczna,
E L Howes, and
D H Char, and
M Christensen
April 1976,
Infection and immunity,
E L Howes, and
D H Char, and
M Christensen
January 1982,
Nippon Ganka Gakkai zasshi,
