Biomaterial Database

Carcinoma of the floor of the mouth. 1982

P J Fitzpatrick, and B S Tepperman

Treatment of 377 patients with squamous cell carcinoma of the floor of the mouth has been studied. Almost two-thirds (235) of the patients had T1 or T2 tumors and a similar number (242) were free of cervical metastases. The median age was 60 years and men predominated over women 4:1. Irradiation, the first treatment of 330 (87.5%) patients, produced a five-year actuarial survival rate of 40%. For stages T1-2 No and T3-4 No such survival rates were 57% and 31% respectively. Regional metastases were the most important prognostic factor and their development reduced survival: if controlled the five-year survival rate was 33% against 17.5% when they were not. Among 221 treated failures, 122 (54%) had persistent disease at three months, and recurrent disease was detected within two years in 93%. A second treatment was successful in 56 (49%) of 115 patients in whom disease recurred either at the primary or secondary sites but only in 13 (24%) of 54 with uncontrolled disease at both sites. Tragically 101 (27%) patients developed other cancers: 69 in the aerodigestive tract and 26 in the lung.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009060	Mouth Floor	The area of the mouth beneath the TONGUE.	Floor of Mouth,Sublingual Region,Floor, Mouth,Floors, Mouth,Mouth Floors,Region, Sublingual,Regions, Sublingual,Sublingual Regions
D009062	Mouth Neoplasms	Tumors or cancer of the MOUTH.	Cancer of Mouth,Mouth Cancer,Oral Cancer,Oral Neoplasms,Cancer of the Mouth,Neoplasms, Mouth,Neoplasms, Oral,Cancer, Mouth,Cancer, Oral,Cancers, Mouth,Cancers, Oral,Mouth Cancers,Mouth Neoplasm,Neoplasm, Mouth,Neoplasm, Oral,Oral Cancers,Oral Neoplasm
D009362	Neoplasm Metastasis	The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011859	Radiography	Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).	Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D001918	Brachytherapy	A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.	Curietherapy,Implant Radiotherapy,Plaque Therapy, Radioisotope,Radioisotope Brachytherapy,Radiotherapy, Interstitial,Radiotherapy, Intracavity,Radiotherapy, Surface,Brachytherapy, Radioisotope,Interstitial Radiotherapy,Intracavity Radiotherapy,Radioisotope Plaque Therapy,Radiotherapy, Implant,Surface Radiotherapy,Therapy, Radioisotope Plaque
D002294	Carcinoma, Squamous Cell	A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D005260	Female		Females