Effects of beta-blockers on type-A coronary-prone behaviour. 1982

A W von Eiff, and G Friedrich, and H Neus, and H Rüddel, and R Schmieder

The influence of coronary-prone behaviour on coronary heart disease is well established, but the link between behavioural and pathophysiological processes is still unknown. A beta-adrenergic hyper-reactivity of type-A subjects is assumed. In this investigation the influence of beta-blockers on the type-A behavior pattern was tested in an inter-individual comparison. Sixteen male hypertensive subjects (stage I or II) were divided at random into two therapeutic groups (beta-blockers vs diuretics). Each patient was given a type-A interview before therapy and at a minimum of 4 weeks after the onset of therapy. Subjects in both groups were similar in age and before therapy they had similar blood pressure at rest as well as similar cardiovascular reactivity and type-A behaviour pattern. After therapy, subjects in the group treated with beta-blockers exhibited less type-A behaviour than those in the group treated with diuretics. The possible influence of the attenuation of the type-A behaviour on the risk of coronary heart disease should be investigated in a prospective study.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010551 Personality Behavior-response patterns that characterize the individual. Personalities
D011412 Propanolamines AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives. Aminopropanols
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003327 Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006852 Hydrochlorothiazide A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. Dichlothiazide,Dihydrochlorothiazide,Esidrex,Esidrix,HCTZ,HydroDIURIL,Hypothiazide,Oretic,Sectrazide

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