Biomaterial Database

[Assessment of the 2,3-diphosphoglycerate content of erythrocytes in diabetes mellitus]. 1982

P N Bodnar, and A M Pristupiuk

The content of 2,3-diphosphoglycerate (2,3-DPG) was studied in the red blood cells of 145 patients with diabetes mellitus. A significant (P less than 0.001) increase in 2,3-DPG (8.10 +/- 0.42 mc mol/l of red blood cells) was seen in the diabetic patients as compared with that of the healthy subjects (4.50 +/- 0.40 mc mol/l ml of red blood cells). A rice in 2,3-DPG concentration is not dependent on the patients' age, duration, severity and type of the disease. The determination of a 2,3-DPG level maybe used for evaluation of tissue hypoxia in patients with diabetes mellitus.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003920	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D004163	Diphosphoglyceric Acids	Glyceric acids where two of the hydroxyl groups have been replaced by phosphates.	Bisphosphoglycerates,Acids, Diphosphoglyceric
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000860	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies
D019794	2,3-Diphosphoglycerate	A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)	2,3-Bisphosphoglycerate,2,3-DPG,2,3-Diphosphoglyceric Acid,2,3-Diphosphoglycerate, (D)-Isomer,Glycerate 2,3-Bisphosphate,2,3 Bisphosphoglycerate,2,3 Diphosphoglycerate,2,3 Diphosphoglyceric Acid,2,3-Bisphosphate, Glycerate