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We report the results of the study of the bronchial concentrations of several antibiotics. The experiment included 280 patients and the concentrations achieved in bronchial secretions were measured for 11 antibiotics. The samples of bronchial secretions were taken in situ by fibroscopy or through the tracheostomy cannula. The results of the study show that the rate of penetration is variable according to the different drugs; even in the same antibiotic family such as beta-lactam antibiotics the rate of penetration is variable. The bronchial levels of aminoglycosides, macrolides and tetracyclines are worthwhile, and are often superior to the MIC of the infecting organisms; the penetration is also dependant of the inflammatory conditions of the bronchi. Otherwise the sampling conditions were the best possible since samples taken by fibroscopy or by tracheostomy are not contaminated by saliva which is a factor of dilutional error. The methodology used in this study is an approach of pharmacokinetics of antibiotics in respiratory tract.
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
January 1981,
Padiatrie und Padologie,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
June 1980,
Revue medicale de Bruxelles,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
September 1978,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
October 1980,
The Japanese journal of antibiotics,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
January 1981,
Revue francaise des maladies respiratoires,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
January 1981,
Le Poumon et le coeur,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
February 1978,
Anales espanoles de pediatria,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
January 1976,
Annali Sclavo; rivista di microbiologia e di immunologia,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
December 1978,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
E Bergogne-Berezin, and
C Morel, and
P Even, and
Y Benard, and
H Kafe, and
G Berthelot, and
J Pierre, and
N Lambert-Zechovsky
May 1978,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
