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The tetramer core of 2'5'-adenylate was tested in vitro for its effect on erythroid colony-forming units (CFU-E) from bone marrow of adult rats. Inhibition of CFU-E was 2'5'-adenylate dose dependent, when tested with concentrations of 0.05- 1.0 mM. Also, 2'5'-adenylate was inhibitory when incubated with 2, 6 or 10 X 10(4) cells/0.1 ml plasma clot. At 0.1 mM concentration of 2'5'-adenylate there was a 30-50% reduction of erythroid colonies for each of these three cell concentrations. There was an early decrease in 3H-thymidine incorporation when 2'5'-adenylate was added to erythropoietin-stimulated bone marrow cell suspensions prior to plating. It is suggested that in situ production of 2'5'-adenylate may represent a regulatory mechanisms in red cell maturation.
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
January 1983,
Cell and tissue kinetics,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
June 1992,
Experimental hematology,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
February 1983,
British journal of haematology,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
January 1981,
Haematology and blood transfusion,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
February 1967,
Science (New York, N.Y.),
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
September 1987,
International journal of cell cloning,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
January 1984,
British journal of haematology,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
November 1986,
The Journal of laboratory and clinical medicine,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
January 1982,
Horizons in biochemistry and biophysics,
D Orlic, and
F Quaini, and
A A Konski, and
J M Wu
May 1992,
Annals of hematology,
