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Cultured Chinese hamster ovary (CHO) cells were incubated with dilutions of natural or synthetic crude oils and subsequently exposed to near ultraviolet light (NUV). Although the magnitude of photo-induced cytotoxicity in CHO was essentially independent of the source of the oil (within a factor of two), two shale oils were exceptionally high in photo-induced mutagenic activity eliciting a response 10-12 times the observed natural background mutation frequency. Other shale oils, natural crude oils and a solvent refined coal medium distillate blend were weaker or negative in photo-induced mutagenic activity. Hydrotreatment of a photoactive shale oil, although eliminating the mutagenic potential, did not reduce the oil's cytotoxic potential.
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
May 1969,
Radiation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
July 1973,
Radiation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
March 1983,
Mutation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
November 1984,
Mutation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
August 1968,
Radiation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
June 1973,
Mutation research,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
December 1973,
Biochimica et biophysica acta,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
June 1971,
Biophysical journal,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
June 1971,
Biophysical journal,
G F Strniste, and
J M Bingham, and
R T Okinaka, and
D J Chen
June 1977,
Mutation research,
