Biomaterial Database

Experiments on cochlear cryosurgery in the guinea pig. Light and surface microscopy. 1982

R Kuylenstierna, and P G Lundquist

The present investigation indicates that with cryosurgery it is possible to produce well defined cochlear lesions. The point of complete ablation can be chosen at will. A great advantage also is the fact that the bony capsule of the labyrinth is left intact. The remarkably slight scarring caused as well as the morphologically intact walls of the cochlear duct indicate an effective healing process, already completed after 6 days. These findings explain the unsuccessful clinical experiences when trying to ablate the labyrinth completely or to induce labyrinthine fistula with the help of cryosurgery (House, 1966). We suggest that for studies on cochlear function after exogenic trauma, cryosurgery gives easy reproductive morphological changes that may help the understanding and correlation of hair cell loss with cochlear physiology.

UI	MeSH Term	Description	Entries
D008857	Microscopy, Interference	The science and application of a double-beam transmission interference microscope in which the illuminating light beam is split into two paths. One beam passes through the specimen while the other beam reflects off a reference mirror before joining and interfering with the other. The observed optical path difference between the two beams can be measured and used to discriminate minute differences in thickness and refraction of non-stained transparent specimens, such as living cells in culture.	Interferometry, Microscopic,Microinterferometry,Microscopy, Differential Interference Contrast,Microscopy, Interference Reflection,Microscopy, Nomarski Interference Contrast,Interference Microscopy,Interference Reflection Microscopy,Microscopic Interferometry,Reflection Microscopy, Interference
D009925	Organ of Corti	The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.	Basilar Papilla,Corti's Organ,Spiral Organ,Corti Organ,Cortis Organ,Organ, Corti's,Organ, Spiral,Organs, Spiral,Papilla, Basilar,Spiral Organs
D003051	Cochlea	The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.	Cochleas
D003452	Cryosurgery	The use of freezing as a special surgical technique to destroy or excise tissue.	Cryoablation,Cryoablations,Cryosurgeries
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006198	Hair Cells, Auditory	Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.	Auditory Hair Cells,Cochlear Hair Cells,Auditory Hair Cell,Cell, Cochlear Hair,Cells, Cochlear Hair,Cochlear Hair Cell,Hair Cell, Auditory,Hair Cell, Cochlear,Hair Cells, Cochlear
D006199	Hair Cells, Auditory, Inner	Auditory sensory cells of organ of Corti, usually placed in one row medially to the core of spongy bone (the modiolus). Inner hair cells are in fewer numbers than the OUTER AUDITORY HAIR CELLS, and their STEREOCILIA are approximately twice as thick as those of the outer hair cells.	Auditory Hair Cell, Inner,Auditory Hair Cells, Inner,Cochlear Inner Hair Cell,Cochlear Inner Hair Cells,Hair Cell, Auditory, Inner,Inner Auditory Hair Cell,Inner Auditory Hair Cells,Inner Hair Cells,Cell, Inner Hair,Cells, Inner Hair,Hair Cell, Inner,Hair Cells, Inner,Inner Hair Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia