RAST and skin test screening in the investigation of asthma. 1982

F A Herbert, and N Weimer, and M L Salkie

We studied 72 adult asthmatics prospectively for the purpose of detecting atopy by the use of screening methods employing total serum IgE, RAST and prick tests. Fifty-one of the patients were considered to be atopic on the basis of prick test reactivity or a positive RAST. Although the total IgE values of the atopic and nonatopic individuals demonstrated some overlap, values over 150 U/mL were found only in atopics. We determined that 89% of the atopic individuals could be detected by a combination of total IgE greater than 150 U/mL and the use of five specific IgE determinations from the frequency of positive RAST to 20 environmental antigens. Ninety percent of the atopics were detected by four prick tests. Regional data are required to develop and effective set of screening tests. The use of such tests can reduce costs and technical time in the investigation of atopy.

UI MeSH Term Description Entries
D006969 Hypersensitivity, Immediate Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability. Atopic Hypersensitivity,Hypersensitivity, Atopic,Hypersensitivity, Type I,IgE-Mediated Hypersensitivity,Type I Hypersensitivity,Atopic Hypersensitivities,Hypersensitivities, Atopic,Hypersensitivities, IgE-Mediated,Hypersensitivities, Immediate,Hypersensitivities, Type I,Hypersensitivity, IgE-Mediated,IgE Mediated Hypersensitivity,IgE-Mediated Hypersensitivities,Immediate Hypersensitivities,Immediate Hypersensitivity,Type I Hypersensitivities
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009098 Multiphasic Screening The simultaneous use of multiple laboratory procedures for the detection of various diseases. These are usually performed on groups of people. Automated Multiphasic Health Testing,Multiphasic Screenings,Screening, Multiphasic,Screenings, Multiphasic
D011852 Radioallergosorbent Test An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies. Radioimmunosorbent Assay of Allergens,Allergens Radioimmunosorbent Assay,Allergens Radioimmunosorbent Assays,Radioallergosorbent Tests,Test, Radioallergosorbent,Tests, Radioallergosorbent
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D012882 Skin Tests Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity. Skin Test,Test, Skin,Tests, Skin

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