BIOMAT Database Logo BIOMAT Database Logo

Basal kinetic studies of Tc-99m DMPE as a myocardial imaging agent in the dog. 1982

H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams

Newly synthesized Tc-99m dichlorobis(1,2-dimethylphosphino)ethane (DMPE) was investigated as a myocardial imaging agent with respect to its kinetics (dependent on both time and regional coronary blood flow), its percent organ uptake, and its imaging characteristics in the anesthetized dog. Most of these data are compared with those of Tl-201. Blood clearance of the two agents is essentially the same. Compared with Tl-201, Tc-99m DMPE shows faster overall kinetics, higher heart-to-lung ratio, equally good correlation with a wide range of regional blood flows, and higher liver uptake. At the time of peak myocardial uptake, the mean heart uptake of Tl-201 is 4.3%, compared with 2.9% for Tc-99m DMPE, yet only 0.9% uptake of Tc-99m DMPE is found in the lung as compared with 3.3% for Tl-201. These differences result in a heart-to-lung ratio of 2:1 for Tc-99m DMPE and 1:1 for Tl-201, based on the data obtained from the time-activity curve. The quantitative findings are supported by the superior quality of Tc-99m DMPE images of both normal and infarcted dog heart. The high hepatic uptake of Tc-99m DMPE is not a serious problem if images are obtained within 5-60 min after dose. These basic kinetic studies suggest that Tc-99m DMPE is a promising myocardial imaging agent.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D010720 Phosphines Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)
D011868 Radioisotopes Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Daughter Isotope,Daughter Nuclide,Radioactive Isotope,Radioactive Isotopes,Radiogenic Isotope,Radioisotope,Radionuclide,Radionuclides,Daughter Nuclides,Daugter Isotopes,Radiogenic Isotopes,Isotope, Daughter,Isotope, Radioactive,Isotope, Radiogenic,Isotopes, Daugter,Isotopes, Radioactive,Isotopes, Radiogenic,Nuclide, Daughter,Nuclides, Daughter
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013667 Technetium The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m Technetium 99m,99m, Technetium
D013793 Thallium A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl. Thallium-205,Thallium 205

Related Publications

H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Preparation, characterization and evaluation of DMPE as a myocardial imaging agent.
March 1983, The International journal of applied radiation and isotopes,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
99m Tc-labeled polyphosphate as a skeletal imaging agent.
March 1972, Radiology,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging.
October 2010, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Evaluation of Tc-99m pyridoxal-phenylalanine as a hepatobiliary imaging agent. Part 1. Experimental studies.
December 1977, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
A new Tc-99m-labeled myocardial imaging agent, hexakis(t-butylisonitrile)-technetium(I) [Tc-99m TBI]: initial experience in the human.
December 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
(99m)Tc-tetrofosmin as a prognostic agent?
January 2006, European journal of nuclear medicine and molecular imaging,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Tc-99m phytate as an imaging agent for lymph nodes.
December 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
The utilization of technetium-99m CPI as a myocardial perfusion imaging agent in exercise studies.
September 1987, Clinical nuclear medicine,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Pharmacokinetic and imaging evaluation of (99m)Tc-HBIDP as a potential bone imaging agent.
May 2015, Pakistan journal of pharmaceutical sciences,
H Nishiyama, and E Deutsch, and R J Adolph, and V J Sodd, and K Libson, and E L Saenger, and M C Gerson, and M Gabel, and S J Lukes, and J L Vanderheyden, and D L Fortman, and K L Scholz, and L W Grossman, and C C Williams
Tc-99m pyrophosphate myocardial imaging in perimyocarditis.
May 1981, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Copied contents to your clipboard!