-transparent.png){kind=logo}
1 The pharmacokinetic parameters of morphine were determined in a crossover fashion following 4 days pretreatment with cimetidine, 300 mg every 6 h, or placebo. 2 Cimetidine had no apparent effect on the mean morphine plasma clearance, volume of distribution, AUC or half-life (P greater than 0.05; power greater than 0.80). 3 Cimetidine had no apparent effect on the magnitude or duration of morphine induced miosis. 4 The absence of a demonstrable effect on the pharmacokinetics of a drug with a high extraction ratio such as morphine suggests that cimetidine did not significantly reduce hepatic blood flow in ambulant normal volunteers.
Related Publications
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
July 1985,
British journal of clinical pharmacology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
November 1995,
International journal of clinical pharmacology and therapeutics,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
January 1998,
Journal of clinical pharmacology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
January 1979,
Hormone research,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
January 1984,
Journal of clinical pharmacology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
December 1984,
British journal of clinical pharmacology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
October 1981,
Clinical immunology and immunopathology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
August 1990,
Journal of clinical pharmacology,
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
October 1971,
Science (New York, N.Y.),
P Mojaverian, and
I L Fedder, and
P H Vlasses, and
H H Rotmensch, and
M L Rocci, and
B N Swanson, and
R K Ferguson
October 1984,
British journal of clinical pharmacology,
