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1 Thirty-six patients with various neurological diseases or symptoms received single intravenous doses of either cimetidine 400 mg (n = 19) or oxmetidine 200 mg (n = 17), 15 or 60 min before a diagnostic lumbar puncture. 2 In the 15 min CSF samples concentrations of cimetidine were detectable but not measurable in 5 and non-detectable in 3 patients. 3 In the 60 min CSF samples the concentrations of cimetidine were detectable in all 11 patients and were measurable in 8 of these patients with a mean +/- s.e. mean of 0.12 +/- 0.01 microgram/ml. These CSF concentrations were correlated to simultaneously measured plasma concentrations (P less than 0.01). The mean ratio CSF/plasma concentration was 0.03. 4 No detectable concentrations of oxmetidine were found either in the 15 min (n = 9) or in the 60 min (n = 8) liquor samples. 5 Cimetidine penetrates the blood-drain barrier slowly and not freely after a single dose. Our data suggest that the new histamine H2-receptor antagonist oxmetidine does not cross this barrier.
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
April 2007,
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K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
July 1992,
British journal of clinical pharmacology,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
March 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
January 1984,
Drug metabolism and disposition: the biological fate of chemicals,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
October 1984,
British journal of clinical pharmacology,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
March 1963,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
March 2015,
Italian journal of pediatrics,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
January 1998,
Antimicrobial agents and chemotherapy,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
June 2008,
British journal of clinical pharmacology,
K A Jönsson, and
S E Eriksson, and
I Kagevi, and
B Norlander, and
G Bodemar, and
A Walan
October 1983,
The Journal of pharmacy and pharmacology,
