-transparent.png){kind=logo}
The tetanus toxin (TT) action on crude glutamic acid decarboxylase (GAD) preparation and GAD activity of synaptosomes were studied. TT was not found to affect GAD, but the GAD activity of synaptosomes isolated from the rat brain cortex increased by 46% after 15 min of incubation in the presence of a dose of 0.1 DLM TT. In some experiments, the GAD activity of a crude synaptosomal fraction isolated from TT affected lumbar segments of the rat spinal cord 48 hours after 0.2 DLM TT injection into the m. gastrocnemius was higher than in the control. If the GAD activity was evaluated in the presence of saturating concentrations of pyridoxal-5-phosphate, the difference in the GAD activities between the control and TT-affected synaptosomes (in vivo and in vitro) was not revealed. These findings allow the suggestion that the TT influences on GABA synthesis are mediated by membrane processes and that they occur at the level of the cofactor and apoenzyme interaction.
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
January 1992,
Toxicon : official journal of the International Society on Toxinology,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
March 1979,
Journal of neurochemistry,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
July 1949,
Hospital (Rio de Janeiro, Brazil),
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
May 1973,
Experientia,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
January 1976,
Naunyn-Schmiedeberg's archives of pharmacology,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
November 1980,
Biochemical pharmacology,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
February 1983,
FEBS letters,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
December 1994,
The Journal of physiology,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
February 1980,
Biulleten' eksperimental'noi biologii i meditsiny,
G N Kryzhanovskiĭ, and
V K Lutsenko, and
O P Sakharova, and
I G Rebrov, and
N G Lutsenko
June 1982,
Psychiatry research,
