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Long-term administration of tamoxifen (3-5 months) in a dose of 0.4 mg/kg to guinea-pigs with estrogen-induced benign uterine tumors had no toxic effects on the animals. Tamoxifen caused no noticeable changes in the ovarian mass, however, 40% of the guinea-pigs manifested ovulation suppression. Analysis of vaginal smears showed that most animals were in the stage of unestrus. Long-term administration of tamoxifen alone did not lead to the development of uterine polyps or tumors. Tamoxifen alone or combined with synestrol provoked a marked decrease in the level of free cytoplasmic estrogen and glucocorticoid receptors in the uterines of the guinea-pigs. In the course of long-term administration of tamoxifen alone, a tendency towards progesterone receptor decrease in the uterus was demonstrated.
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
January 1977,
Acta physiologica et pharmacologica Bulgarica,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
February 1940,
The Journal of physiology,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
September 1965,
Archives internationales de pharmacodynamie et de therapie,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
April 1964,
Endocrinology,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
April 1979,
Clinical and experimental immunology,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
June 1953,
Il Policlinico. Sezione pratica,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
August 1950,
Nature,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
March 1915,
Science (New York, N.Y.),
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
January 2007,
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP,
N I Murav'eva, and
Z V Kuz'mina, and
K D Smirnova, and
E S Gershteĭn, and
E A Ird
January 1958,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
