BIOMAT Database Logo BIOMAT Database Logo

[Activation of the membrane toxicity and cytotoxicity of the tumor cell by leukocyte and fibroblast interferon]. 1982

A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks

The effect of exogenous interferon on membrane toxicity and cytotoxicity of mouse tumor cells (MX-II, SA-I, thymomas, IAC) was studied with respect to target IAC-I cells. The treatment with leukocyte interferon made tumor cell membrane toxicity rise by 27-40%, while that with fibroblast one by 30-47%. As a result of the treatment with leukocyte interferon, tumor cell cytotoxicity increased by 26-47%. Antiserum against fibroblast interferon reversed its activation effect on tumor cells. It is assumed that the effect described is linked with the increased resistance of tumor cells as regards normal killers under interferon action.

UI MeSH Term Description Entries
D007370 Interferon Type I Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). Interferons Type I,Type I Interferon,Type I Interferons,Interferon, Type I,Interferons, Type I
D008223 Lymphoma A general term for various neoplastic diseases of the lymphoid tissue. Germinoblastoma,Lymphoma, Malignant,Reticulolymphosarcoma,Sarcoma, Germinoblastic,Germinoblastic Sarcoma,Germinoblastic Sarcomas,Germinoblastomas,Lymphomas,Lymphomas, Malignant,Malignant Lymphoma,Malignant Lymphomas,Reticulolymphosarcomas,Sarcomas, Germinoblastic
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D003602 Cytotoxicity, Immunologic The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Tumoricidal Activity, Immunologic,Immunologic Cytotoxicity,Immunologic Tumoricidal Activities,Immunologic Tumoricidal Activity,Tumoricidal Activities, Immunologic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012513 Sarcoma, Experimental Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. EHS Tumor,Sarcoma, Engelbreth-Holm-Swarm,Sarcoma, Jensen,Experimental Sarcoma,Experimental Sarcomas,Sarcomas, Experimental,Engelbreth-Holm-Swarm Sarcoma,Jensen Sarcoma,Sarcoma, Engelbreth Holm Swarm,Tumor, EHS
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D013945 Thymoma A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed) Carcinoma, Thymic,Carcinomas, Thymic,Thymic Carcinoma,Thymic Carcinomas,Thymomas

Related Publications

A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle.
March 1979, The Journal of general virology,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Suppressor T cell activation by human leukocyte interferon.
November 1983, Journal of immunology (Baltimore, Md. : 1950),
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon.
July 1981, Journal of clinical immunology,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Regulation of human natural killer cell cytotoxicity by recombinant leukocyte interferon clone A.
January 1983, Journal of biological response modifiers,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferon.
October 1978, International journal of cancer,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Characteristics of macrophage activation by gamma interferon for tumor cytotoxicity in peritoneal macrophages and macrophage cell line J774.1.
January 1989, Microbiology and immunology,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Activation of macrophage tumor cytotoxicity by the synergism of two T cell-derived lymphokines: immune interferon (IFN-gamma) and macrophage cytotoxicity-inducing factor 2 (MCIF2).
January 1985, European journal of immunology,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
[Regulation of expression of human fibroblast interferon gene by human leukocyte interferon and cytopathogenic alpha-virus].
February 1998, Biulleten' eksperimental'noi biologii i meditsiny,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Polymorphonuclear leukocyte tumor cell cytotoxicity: a new method of quantitation.
January 1977, Surgical forum,
A G Sterlina, and V V Malinovskaia, and I V Bogdashin, and B B Fuks
Interferon-gamma is required in activation of macrophages for tumor cytotoxicity.
July 1983, Cellular immunology,
Copied contents to your clipboard!