-transparent.png){kind=logo}
The effect of cytoplasms on the expression of tumorigenicity was examined in interspecific reconstituted cells and cytoplasmic hybrids (cybrids) formed by fusions between karyoplasts (or intact cells) from highly tumorigenic mouse melanoma B16 cells and cytoplasts from non-tumorigenic, hypoxanthine-guanine phosphoribosyl-transferase (HGPRT)-deficient and chloramphenicol (CAP)-resistant rat myoblastic cells, L6TG X CAPr. The reconstituted clones and cybrid clones isolated in the double selection medium, HAT and CAP, acquired CAP-resistance, and each showed unique morphology and cellular arrangement. Tumorigenicity was suppressed in all the reconstituted clones and cybrid clones examined at an early stage after their isolation, but re-appeared in some clones after prolonged cultivation of the cells.
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
January 1981,
Journal of supramolecular structure and cellular biochemistry,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
August 1982,
FEBS letters,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
August 1980,
FEBS letters,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
May 1978,
Proceedings of the National Academy of Sciences of the United States of America,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
January 1987,
Methods in enzymology,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
January 1993,
In vivo (Athens, Greece),
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
December 1980,
Experimental cell research,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
January 1984,
Gan,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
February 1988,
Cancer research,
M Koura, and
H Isaka, and
M C Yoshida, and
M Tosu, and
T Sekiguchi
July 1988,
Somatic cell and molecular genetics,
