[Evaluation of early coronary artery reconstruction in acute myocardial infarction--time limit in the therapeutic effectiveness in relation to restoration of localized myocardial contraction]. 1982

H Honma

The effects of 1 hour, 3 hours and 10 days coronary artery reperfusion after 20 minutes, 40 minutes, 3 hours, 4 hours and 5 hours coronary artery occlusion on the contractility of myocardium was studied by the strain gauge arch, and the myocardial changes was also studied histologically. Results obtained were follows. In the short term reperfusion study: 1) Dyskinesis disappeared in all cases if reperfusion was begun after 20 minutes of ischemia. 2) Dyskinesis remained in all cases if reperfusion was begun after 40 minutes of ischemia. In the long term reperfusion study: 3) Dyskinesis disappeared in all cases after 10 days reperfusion with 3 and 4 hours ischemia groups, and the recovery of myocardial contractility was good. 4) Dyskinesis remained in 2 of 5 dogs with 5 hours coronary occulusion even after 10 days of reperfusion, and the recovery of myocardial contractility in 3 of 5 dogs with this group was poor. It is concluded that revascularization of myocardium that has been kept ischemia for less than 4 hours may lead to disappearance of dyskinesis and recovery of myocardial contractility. These findings also indicate that early coronary revascularization does not always provide an immediate recovery of dyskinesis of the revascularized area.

UI MeSH Term Description Entries
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D009204 Myocardial Revascularization The restoration of blood supply to the myocardium. (From Dorland, 28th ed) Internal Mammary Artery Implantation,Myocardial Revascularizations,Revascularization, Myocardial,Revascularizations, Myocardial
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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