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The carboxylic acid anions are shown to inhibit lactate dehydrogenase in a non-competitive manner at pH 8.5. The inhibitory effect of different carboxylates used increases in the direction acetate leads to formate leads to methacrylate. Non-competitive inhibition by carboxylates has a non-linear character with effective Hill exponent depending on the inhibitor concentration increasing to the value n approximately equal to 2 when inhibitor concentration increases. The kinetic model is proposed to account for non-linear non-competitive inhibition in consequence of the abortive ternary complexes formation in two enzyme conformations. The substrate analogues properties that result in non-competitive inhibition of lactatedehydrogenase are considered.
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
August 2018,
MedChemComm,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
September 1977,
European journal of biochemistry,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
October 1990,
Biokhimiia (Moscow, Russia),
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
January 1978,
Molekuliarnaia biologiia,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
February 1992,
Biochemical and biophysical research communications,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
April 1966,
Nature,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
May 1973,
Biochemistry,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
December 1965,
Science (New York, N.Y.),
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
January 1973,
Archives of biochemistry and biophysics,
E A Saburova, and
B N Gol'dshteĭn, and
L I Elfimova, and
M V Vol'kenshteĭn
January 1971,
Acta biologica et medica Germanica,
