Biomaterial Database

Changes in the metabolic clearance rate and plasma production rate of testosterone in the pregnant guinea-pig. 1982

G Despres, and N Rigaudière, and P Delost

The metabolic clearance rate of testosterone (MCRT) in the pregnant and non-pregnant guinea-pig was established by a constant infusion method to steady state levels of 3H testosterone (T). Simultaneously, the concentration of endogenous T was determined by radioimmunoassay and the production rate of T (PRT) was calculated from the product of MCRT and endogenous T concentration. Results indicate important alterations in the three parameters between non-pregnant (MCRT = 64.0 +/- 2.6 1/24 hr; T concentration = 51 +/- 8 pg/ml; PRT = 3.24 +/- 0.13 micrograms/24 h) and the pregnant guinea-pig. In these animals mean values from day 43 were about 33 1/24 h for MCRT, 378 pg/ml for T concentrations and 12.5 micrograms/24 h for PRT. The significance of these results is discussed in relation to the specific binding of testosterone with the progesterone binding globulin during pregnancy in this species.

UI	MeSH Term	Description	Entries
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011270	Pregnancy, Animal	The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.	Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D005260	Female		Females
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013739	Testosterone	A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.	17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone