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The effect of the two C-17 isomers of estradiol on the shape of the action potential of rat atrial tissue was studied by means of classical glass electrodes for different concentrations of estradiol. Resting potential and upstroke were not affected by estradiol, but the duration of the action potential was reduced. Only estradiol-17 beta exhibits an effect in a concentration dependent way, while estradiol-17 alpha has no effect at all. The ionic mechanism was studied by adding specific ionic blockers to the perfusate. Since the effect was much less pronounced when a slow inward current blocker was added, it was concluded that estradiol-17 beta acts mainly via the slow inward current channel. Only a small part of the interaction takes place via the potassium outward channel.
E L de Beer, and
H A Keizer
December 1983,
Biology of reproduction,
E L de Beer, and
H A Keizer
January 1965,
Prensa medica argentina,
E L de Beer, and
H A Keizer
January 1966,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
E L de Beer, and
H A Keizer
April 1965,
American journal of obstetrics and gynecology,
E L de Beer, and
H A Keizer
July 1963,
La Semana medica,
E L de Beer, and
H A Keizer
March 1964,
American journal of obstetrics and gynecology,
E L de Beer, and
H A Keizer
March 1990,
Proceedings of the National Academy of Sciences of the United States of America,
E L de Beer, and
H A Keizer
June 1971,
The Journal of clinical endocrinology and metabolism,
E L de Beer, and
H A Keizer
November 1987,
Cancer research,
E L de Beer, and
H A Keizer
January 1965,
Revista de la Sociedad Argentina de Biologia,
