Biomaterial Database

[Drug modification of contractions of fetoplacental vessels of bilaterally in vitro perfused human placentas]. 1982

H Nöschel, and W Reiber, and S Schröder

Studies were conducted into the effects of 20 medicaments on contraction of fetoplacental vessels in human placenta with bilateral in vitro perfusion. The presence of alpha receptors in the foetal vessels was concluded from the latter's response to alpha mimetics and alpha blockers, whereas beta receptors and muscarinergic receptors were not recordable from blood vessels of the full-term placenta. Medicaments with established vasodilatating action caused vasodilatation also in fetoplacental vessels, with most intensive effects being recorded from application of aminophylline and nitrangin. Strong vascular contraction was recorded in response to prostaglandin F2 alpha. The same type of studies was applied to other medicaments of common use in obstetrics. The method may be an experimental contribution to therapeutic medication of patients with acute or chronic impairment of fetoplacental blood supply.

UI	MeSH Term	Description	Entries
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D001808	Blood Vessels	Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).	Blood Vessel,Vessel, Blood,Vessels, Blood
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014665	Vasodilator Agents	Drugs used to cause dilation of the blood vessels.	Vasoactive Antagonists,Vasodilator,Vasodilator Agent,Vasodilator Drug,Vasorelaxant,Vasodilator Drugs,Vasodilators,Vasorelaxants,Agent, Vasodilator,Agents, Vasodilator,Antagonists, Vasoactive,Drug, Vasodilator,Drugs, Vasodilator
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In