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We report the effects of cetiedil, a new antisickling agent, on red cell membrane permeability. With fresh red cells containing normal levels of intracellular ATP, cetiedil increases membrane permeability to both sodium and potassium. With drug concentrations from 100 to 500 microM, net sodium gain exceeds net potassium loss, and the cells quickly swell. Changes are identical with normal and sickle red cells. Membrane permeability returns to normal after washing the cells in buffer free of cetiedil. In the absence of phosphate, ouabain potentiates the cetiedil effect. With external phosphate present, the effect of cetiedil is also enhanced, but ouabain is without effect. Our findings support the idea that the antisickling effect of cetiedil observed in vitro is secondary to cell swelling.
W F Schmidt, and
T Asakura, and
E Schwartz
November 1981,
The Journal of clinical investigation,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1957,
Progress in biophysics and biophysical chemistry,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1998,
Romanian journal of physiology : physiological sciences,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1974,
The Journal of membrane biology,
W F Schmidt, and
T Asakura, and
E Schwartz
December 1998,
Proceedings of the National Academy of Sciences of the United States of America,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1982,
Blood cells,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1989,
ASAIO transactions,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1966,
Acta physiologica Academiae Scientiarum Hungaricae,
W F Schmidt, and
T Asakura, and
E Schwartz
January 1974,
Biophysical journal,
W F Schmidt, and
T Asakura, and
E Schwartz
November 1975,
Postgraduate medical journal,
