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BrdU-incorporation techniques were used to study the cell cycle in 18 cases of Fanconi's anemia (FA). By comparison with controls, a significant slowing of the cell cycle of lymphocytes in vitro was observed in all FA patients, and possibly in FA heterozygotes, although to a lesser degree. It is probable that the demonstration of the slowing is dependent on the culture conditions. No slowing was observed in other patients affected by at least one of the symptoms of FA. The slow cell cycle of FA cells is mostly due to a very long G2-phase. A relationship between slow cell cycle and chromatid anomalies exists, the slower cells being significantly more frequently carriers of radial figures than the faster cells, in the same patient.
B Dutrillaux, and
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August 1993,
Cancer genetics and cytogenetics,
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D Buriot, and
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January 2014,
F1000prime reports,
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A M Dutrillaux, and
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February 2018,
Stem cell reports,
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A M Dutrillaux, and
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April 1995,
Blood,
B Dutrillaux, and
A Aurias, and
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D Buriot, and
M Prieur
May 2008,
Blood,
B Dutrillaux, and
A Aurias, and
A M Dutrillaux, and
D Buriot, and
M Prieur
December 2001,
Molecular genetics and metabolism,
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A Aurias, and
A M Dutrillaux, and
D Buriot, and
M Prieur
June 2013,
Mutation research,
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A Aurias, and
A M Dutrillaux, and
D Buriot, and
M Prieur
January 1991,
Annales de genetique,
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A Aurias, and
A M Dutrillaux, and
D Buriot, and
M Prieur
November 1997,
Somatic cell and molecular genetics,
B Dutrillaux, and
A Aurias, and
A M Dutrillaux, and
D Buriot, and
M Prieur
February 1996,
Experimental cell research,
