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Of 100 consecutive patients with recurrent renal calculi, 43 had idiopathic hypercalciuria (IH) on outpatient evaluation. Hypercalciuria was classified as diet-dependent or fasting; all patients had normal serum iPTH and urinary cyclic AMP, and serum phosphate and TmPO4/GFR were reduced in IH compared to normocalciuric stone formers. In 16 patients with IH, clearance studies revealed an elevated urine flow are factored for GFR (V/GFR) as compared with normal controls (p less than 0.05). In 12 patients, serum PTH was normally suppressed by calcium infusion but TmPO4/GFR was persistently reduced. Acute and chronic phosphate administration significantly reduced urine calcium excretion but did not correct the abnormal V/GFR. We conclude that in IH of both the fasting and the diet-dependent type, there is a defect in the proximal tubular reabsorption of sodium and fluid as well as PTH-independent tubular phosphate wasting. The proximal tubular defect is not a consequence of hypercalciuria nor of phosphate depletion but may be a cause of these abnormalities.
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
January 2006,
Acta medica (Hradec Kralove),
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
April 1985,
Medicina clinica,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
January 1983,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
February 1986,
Australian and New Zealand journal of medicine,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
January 1984,
Nephrologie,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
June 1987,
Lancet (London, England),
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
October 1970,
Revista clinica espanola,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
June 1994,
The American journal of physiology,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
January 1968,
Rassegna di neurologia vegetativa,
Y K Lau, and
A Wasserstein, and
G R Westby, and
P Bosanac, and
M Grabie, and
P Mitnick, and
E Slatopolsky, and
S Goldfarb, and
Z S Agus
October 2000,
Physiological reviews,
