[Congenital intraspinal neuroblastomas. A propos of 7 cases treated surgically]. 1982

C Sainte-Rose, and F X Roux, and A Pierre-Kahn, and D Renier, and J F Hirsch

Neuroblastomas appear to be one of the most frequent congenital solid tumors. Nevertheless, intraspinal congenital neuroblastomas are uncommon. The authors report seven cases of congenital intraspinal neuroblastomas operated on in the "Service de Neurochirurgie des Enfants-Malades" from 1970 to 1980. Their study and that of 16 cases published in the literature allows to stress several points (7, 12). The dumb-bell intraspinal neuroblastomas present a large extension. They usually determine a severe and definitive paraplegia. They probably have a long prenatal evolution. The tumoral prognosis of these congenital neuroblastomas is good. Success should be expected in nearly 80% of the cases. Surgery, in two steps, intra and extra spinal, remains compulsory even though the neurological prognosis is poor. It is useless to operate upon the neuroblastomas as emergencies, when neurological involvement is total at birth. The complementary treatment, X ray-therapy or chemotherapy is not without any danger on newborns. It necessary is not proved.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D009447 Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) Neuroblastomas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013115 Spinal Canal The cavity within the SPINAL COLUMN through which the SPINAL CORD passes. Vertebral Canal,Vertebral Foramen,Vertebral Foramina,Canal, Spinal,Canal, Vertebral,Foramen, Vertebral,Foramina, Vertebral,Spinal Canals,Vertebral Canals,Vertebral Foramens
D013125 Spinal Neoplasms New abnormal growth of tissue in the SPINE. Neoplasm, Spinal,Neoplasms, Spinal,Spinal Neoplasm

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