BIOMAT Database Logo BIOMAT Database Logo

The ocular hypotensive effect of timolol in long-term treatment of glaucoma. A 4 year study. 1982

N V Nielsen

The ocular hypotensive action of timolol used alone and in combination with other antiglaucoma drugs was studied in 33 patients with glaucoma, 19 glaucoma suspects and 12 patients with ocular hypertension in a treatment period of 4 years. During the 2nd-4th year the mean IOP increased 8-10% (P less than 0.05) in both glaucoma patients and patients with ocular hypertension or suspected glaucoma. The success rate on timolol alone (a persistent IOP less than 20 mmHg) was 43.6% in patients with manifest glaucoma. In 18% of the patients an aggravation of pre-existing visual field lesion or new visual lesions developed. Nine patients (14%) - 3 on timolol alone and 6 on additional treatment regime - had to be operated due to definite insufficiency of pressure reduction.

UI MeSH Term Description Entries
D008297 Male Males
D011412 Propanolamines AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives. Aminopropanols
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D005901 Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed) Glaucomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D013999 Timolol A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor. (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol,2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-,Blocadren,L-714,465,MK-950,Optimol,Timacar,Timolol Hemihydrate,Timolol Maleate,Timolol Maleate, (1:1) Salt,Timoptic,Timoptol,L 714,465,L714,465,MK 950,MK950

Related Publications

N V Nielsen
Long-term ocular hypotensive effect of levobunolol: results of a one-year study.
August 1985, The British journal of ophthalmology,
N V Nielsen
[2-year long-term treatment of chronic glaucoma with timolol eyedrops].
January 1979, Bulletin des societes d'ophtalmologie de France,
N V Nielsen
[Short and long-term hypotensive effect of timolol-gel and latanoprost instillation in normal-tension glaucoma].
August 2004, Nippon Ganka Gakkai zasshi,
N V Nielsen
The long-term hypotensive effect of timolol maleate compared with the effect of pilocarpine in simple and capsular glaucoma.
June 1979, Acta ophthalmologica,
N V Nielsen
[Ocular hypotensive effect of low doses of timolol].
January 1987, Vestnik oftalmologii,
N V Nielsen
Ocular hypotensive effect of sublingual administration of timolol.
January 1996, International ophthalmology,
N V Nielsen
Ocular hypotensive effect of topical ketanserin in timolol users.
March 1997, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
N V Nielsen
Timolol treatment of chronic open-angle glaucoma and ocular hypertension. A 2.5-year multicenter study.
January 1982, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
N V Nielsen
[Results of long-term treatment of glaucoma with timolol].
July 1980, Ceskoslovenska oftalmologie,
N V Nielsen
Long-term effect of latanoprost/timolol fixed combination in patients with glaucoma or ocular hypertension: a prospective, observational, noninterventional study.
September 2010, BMC ophthalmology,
Copied contents to your clipboard!