Biomaterial Database

Clinical and etiological aspects of senile dementia. 1982

H Soininen, and O P Heinonen

Some clinical and etiological aspects of senile dementia of the Alzheimer type (SDA) were elucidated in a case control study of 63 SDA patients and 91 controls. The SDA patients had significantly more commonly both senile and presenile dementia in parents and sibs than the controls. The occurrence of senile dementia in parents or sibs increased the risk for SDA by about 900% when all other relevant factors were taken into account in multiple logistic risk function analysis. The increase of the risk for SDA associated with the occurrence of presenile dementia in sibs was even greater but not statistically significant because of other factors and sample size. There was a negative correlation between the occurrence of hypertension and angina pectoris and SDA, which may be partly due to selective diagnostic criteria of SDA. The beta-globulin fraction of cerebrospinal fluid was significantly reduced in the electrophoresis in the SDA patients compared with the controls.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009460	Neurologic Examination	Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.	Examination, Neurologic,Neurological Examination,Examination, Neurological,Examinations, Neurologic,Examinations, Neurological,Neurologic Examinations,Neurological Examinations
D003704	Dementia	An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D004171	Diploidy	The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.	Diploid,Diploid Cell,Cell, Diploid,Cells, Diploid,Diploid Cells,Diploidies,Diploids
D005260	Female		Females
D006454	Hemoglobins	The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.	Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014280	Triglycerides	An ester formed from GLYCEROL and three fatty acid groups.	Triacylglycerol,Triacylglycerols,Triglyceride