-transparent.png){kind=logo}
Expression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four different VH DNA probes under conditions that permitted cross-hybridization between distantly related VH genes. In contrast, VH gene expression was readily detected in two B cell lymphomas and in splenic B cells. Less than one molecule per cell of RNA, exactly complementary to the DNA probes used, would have been detected in these T cell populations. The results thus seriously question the proposition that T cells use the B cell VH repertoire to code for antigen receptors.
Related Publications
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
July 1976,
Proceedings of the National Academy of Sciences of the United States of America,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
September 1976,
British medical bulletin,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
November 1974,
Annals of the New York Academy of Sciences,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
June 1974,
Proceedings of the National Academy of Sciences of the United States of America,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
September 1980,
Science (New York, N.Y.),
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
January 1977,
European journal of immunology,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
July 1977,
The Journal of biological chemistry,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
August 2002,
Nucleic acids research,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
July 1977,
The Journal of biological chemistry,
D J Kemp, and
J M Adams, and
P L Mottram, and
W R Thomas, and
I D Walker, and
J F Miller
January 1982,
The Journal of biological chemistry,
