-transparent.png){kind=logo}
The mutagenicity of 4 known intercalating agents acridine orange (AO), quinacrine mustard (QM), proflavin (PF) and ethidium bromide (EB) has been investigated in L5178Y mouse lymphoma cells. Methyl methanesulfonate (MMS) was used as a positive control in these studies. AO, QM and PF induced mutation in the excess thymidine- and thioguanine-selective systems. These 3 compounds were negative in the ouabain- and cytosine-arabinoside-selective systems while EB was positive only in the cytosine arabinoside system. It would appear that the EB-induced mutagenesis is different from that of AO, QM and PF though all are intercalating agents. Since the molecular origin of cytosine arabinoside mutants is unknown, further interpretation of the EB results is not possible.
A M Rogers, and
K C Back
January 1987,
Environmental mutagenesis,
A M Rogers, and
K C Back
September 1987,
Mutation research,
A M Rogers, and
K C Back
January 1987,
Mutation research,
A M Rogers, and
K C Back
March 1982,
Journal of toxicology and environmental health,
A M Rogers, and
K C Back
March 1987,
Mutation research,
A M Rogers, and
K C Back
January 1984,
Mutation research,
A M Rogers, and
K C Back
November 2005,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A M Rogers, and
K C Back
January 1982,
Mutation research,
A M Rogers, and
K C Back
March 1986,
Mutagenesis,
A M Rogers, and
K C Back
November 1995,
Mutation research,
