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A significant rise in antibody against pneumococcal types 3, 6A and 25 after pneumococcal vaccination could be demonstrated in 26 of 30 individuals (87%) using an enzyme-linked immunosorbent assay. Similar geometric mean antibody fold increases were found in splenectomized children, non-splenectomized children and healthy adults for types 6A and 25. Splenectomized children exhibited a somewhat lower, but not statistically significant, geometric mean antibody fold increase against type 3 (p = 0.10), as compared to non-splenectomized children. For the whole group a negative correlation could be demonstrated between prevaccination antibody concentration and antibody fold increase after vaccination. After vaccination an enhanced serum opsonic activity against type 3 was found by granulocyte glucose-l-14C oxidation for the whole group of 30 patients (p less than 0.05) but nine individual patients (30%) failed to exhibit an increase. No differences between the three patient groups were demonstrable. Changes in serum opsonic activity could not be detected by a pneumococcal bactericidal assay.
K S Johansen, and
F K Pedersen
May 1982,
Acta paediatrica Scandinavica,
K S Johansen, and
F K Pedersen
April 1983,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology,
K S Johansen, and
F K Pedersen
May 1985,
Archives francaises de pediatrie,
K S Johansen, and
F K Pedersen
January 1990,
Scandinavian journal of infectious diseases,
K S Johansen, and
F K Pedersen
October 1984,
The Journal of pediatrics,
K S Johansen, and
F K Pedersen
September 1999,
The American surgeon,
K S Johansen, and
F K Pedersen
July 1959,
The New England journal of medicine,
K S Johansen, and
F K Pedersen
March 1980,
The Journal of infectious diseases,
K S Johansen, and
F K Pedersen
October 1982,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology,
K S Johansen, and
F K Pedersen
January 2006,
Vaccine,
