-transparent.png){kind=logo}
Digoxin is converted to cardioinactive reduced metabolites (DRP) in vivo and in vitro by the human gut flora. Digoxin inactivation is mediated by Eubacterium lentum, a normal inhabitant of the gastrointestinal flora. E. lentum appears to be the sole organism performing this reaction. Fecal bacteria that convert digoxin to DRP in vitro have been found to be present in some subjects who fail to make DRP in vivo. DRP-forming E. lentum have been isolated from the stools of two such subjects. When increasing amounts of arginine are supplied as a growth substrate to E. lentum, bacterial growth and DRP production vary inversely. Further study will be required to identify the factors which determine why digoxin is inactivated in vivo by the gut flora of certain patients and not by others.
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
March 1976,
Journal of bacteriology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
April 1987,
Applied and environmental microbiology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
June 1986,
Applied and environmental microbiology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
October 1981,
The New England journal of medicine,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
October 2006,
Medicina clinica,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
November 1981,
Applied and environmental microbiology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
July 1989,
Gut,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
April 1984,
Applied and environmental microbiology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
April 1993,
Journal of clinical microbiology,
J F Dobkin, and
J R Saha, and
V P Butler, and
H C Neu, and
J Lindenbaum
April 1983,
Science (New York, N.Y.),
