Bone marrow granulomas and neutropenia associated with procainamide. Report of a case. 1978

J Riker, and J Baker, and M Swanson

Bone marrow granulomas and neutropenia occurred in a 77-year-old man following the ingestion of procainamide hydrochloride for 50 days. Although neutropenia has occasionally occurred following procainamide therapy, granulomas in the bone marrow have not previously been associated with the use of this drug. There was no other apparent agent that could have been responsible for the granulomas. Eighteen days after administration of the drug had been discontinued, the WBC count returned to normal and there were no granulomas present in the bone marrow.

UI MeSH Term Description Entries
D008297 Male Males
D009503 Neutropenia A decrease in the number of NEUTROPHILS found in the blood. Neutropenias
D011342 Procainamide A class Ia antiarrhythmic drug that is structurally-related to PROCAINE. Procaine Amide,Apo-Procainamide,Biocoryl,Novocainamide,Novocamid,Procainamide Hydrochloride,Procamide,Procan,Procan SR,Procanbid,Pronestyl,Rhythmin,Amide, Procaine,Hydrochloride, Procainamide
D001855 Bone Marrow Diseases Diseases involving the BONE MARROW. Bone Marrow Disease,Disease, Bone Marrow,Diseases, Bone Marrow,Marrow Disease, Bone,Marrow Diseases, Bone
D006099 Granuloma A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents. Granulomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000380 Agranulocytosis A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS). Granulocytopenia,Agranulocytoses,Granulocytopenias

Related Publications

J Riker, and J Baker, and M Swanson
May 1985, New York state journal of medicine,
J Riker, and J Baker, and M Swanson
January 2019, Reumatologia clinica,
J Riker, and J Baker, and M Swanson
November 1979, Clinical immunology and immunopathology,
J Riker, and J Baker, and M Swanson
June 1992, Southern medical journal,
J Riker, and J Baker, and M Swanson
July 2000, Pharmacotherapy,
J Riker, and J Baker, and M Swanson
May 2017, Revista medica de Chile,
J Riker, and J Baker, and M Swanson
April 2003, The International journal of eating disorders,
J Riker, and J Baker, and M Swanson
February 1984, Annals of internal medicine,
J Riker, and J Baker, and M Swanson
July 2013, Blood,
J Riker, and J Baker, and M Swanson
August 1990, Israel journal of medical sciences,
Copied contents to your clipboard!