Biomaterial Database

[Application of nude mouse-human cancer xenograft system for sensitivity test of anticancer drugs]. 1982

M Fujita, and T Taguchi

The usefulness of the nude mouse-human cancer xenograft system for a sensitivity test of chemotherapeutic drugs is evaluated. In our present study, the response of 9 experimental chemotherapies on 7 lines of cancer xenografts in nude mice was directly compared with clinical response in each donor patient, to the same chemotherapy and good correlation was found between these respective results. Experimental studies on chemotherapeutic effects on 14 lines of cancer xenografts (7 gastric, 3 colorectal, 3 breast and 1 pancreatic cancer) using 5 clinically active and 5 new drugs, were also conducted Although every line of xenograft retained different patterns of sensitivity to the various agents, drugs which were clinically effective to a type of tumor were found to be also sensitive against the same type of xenografts in nude mice. Thus the nude-mice human cancer system were is thought to be useful as a predictive secondary screening for new drugs. However, further improvement is necessary to establish this system as a more accurate selection method for anti-cancer drugs.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008819	Mice, Nude	Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.	Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009374	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D004351	Drug Resistance	Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.	Resistance, Drug
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults