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The antitumor effect of Corynebacterium parvum (C. parvum) was examined by using C3H/He mouse bearing MH-134 ascites hepatoma. The optimal dose of C. parvum was 0.4mg/day intraperitoneally for 5 consecutive days from the 5th day after tumor inoculation. The cell-mediated immunity in this treatment was also investigated by delayed type hypersensitivity (DTH) and macrophage migration inhibition activity (MI). According to the results of both DTH and MI, it was assumed that C. parvum yielded an antitumor effect by restoring the cell-mediated immunity of the tumor bearing host.
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