Biomaterial Database

Inhibition of adenosine deaminase by deaza derivatives of adenosine and purine riboside. 1982

G Lupidi, and F Riva, and G Cristalli, and M Grifantini

Deaza analogs of adenosine, where carbon substitutes for nitrogen, are not substrates for adenosine deaminase (adenosine aminohydrolase EC 3.5.4.4); little is reported on their ability to be inhibitors. Among the deaza analogs of adenosine and purine riboside that we have been testing, 1-deazaadenosine proved to be the best inhibitor (Ki = 6.6 X 10(-7)M). 1-deazapurine riboside, 1,3-dedeazadenosine, 3-deazaadenosine have affinity by about two and three order of magnitude lower.

UI	MeSH Term	Description	Entries
D007422	Intestines	The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.	Intestine
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D009700	Nucleoside Deaminases	Catalyze the hydrolysis of nucleosides with the elimination of ammonia.	Deaminases, Nucleoside
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012263	Ribonucleosides	Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
D014372	Tubercidin	An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.	7-Deazaadenosine,4-Amino-7 beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine,Deazaadenosine,7 Deazaadenosine
D058892	Adenosine Deaminase Inhibitors	Drugs that inhibit ADENOSINE DEAMINASE activity.	ADA Inhibitors,Deaminase Inhibitors, Adenosine,Inhibitors, ADA,Inhibitors, Adenosine Deaminase