BIOMAT Database Logo BIOMAT Database Logo

Comparison between subcutaneous and conjunctival route of vaccination with Rev. 1 strain against Brucella melitensis infection in ewes. 1982

R Fensterbank, and P Pardon, and J Marly

In areas where the prevalence of Brucella melitensis infection in sheep is high, control of the disease cannot be led without the help of vaccination. The use of Brucella melitensis strain Rev. 1 vaccine affords a very good protection. The drawback is that this vaccine, giving rise to long-lasting antibody titers, may disturb serological screening when a return is made to a test and slaughter policy, after several years of vaccination. There is a great need for another mode of vaccination which would avoid this disadvantage. In this experiment, the potency of a vaccination by conjunctival route with 1.4 X 10(8) Rev. 1, plus a recall of 2.9 X 10(8) six months later, was compared with that of the normal subcutaneous vaccination with 1.4 or 2.7 X 10(9) Rev. 1. The vaccination by conjunctival route afforded a somewhat better protection than the subcutaneous one, and with a shorter serological response. It may be possible that a single conjunctival vaccination, avoiding the difficulties of vaccinating twice in ovine flocks and giving few antibodies, could also afford a good protection. Research in progress should include investigation of this point.

UI MeSH Term Description Entries
D007267 Injections Introduction of substances into the body using a needle and syringe. Injectables,Injectable,Injection
D007279 Injections, Subcutaneous Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin. Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D002004 Brucella Vaccine A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats. Vaccine, Brucella
D002006 Brucellosis Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss. Malta Fever,Undulant Fever,Brucella Infection,Brucellosis, Pulmonary,Cyprus Fever,Gibraltar Fever,Rock Fever,Brucella Infections,Brucelloses,Brucelloses, Pulmonary,Fever, Cyprus,Fever, Gibraltar,Fever, Malta,Fever, Rock,Fever, Undulant,Infection, Brucella,Pulmonary Brucelloses,Pulmonary Brucellosis
D003228 Conjunctiva The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball. Bulbar Conjunctiva,Palpebral Conjunctiva,Plica Semilunaris of Conjunctiva,Plicae Semilunares of Conjunctiva,Tunica Conjunctiva,Conjunctiva, Bulbar,Conjunctiva, Palpebral,Conjunctivas
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012757 Sheep Diseases Diseases of domestic and mountain sheep of the genus Ovis. Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease

Related Publications

R Fensterbank, and P Pardon, and J Marly
Conjunctival vaccination of young goats with Brucella melitensis strain Rev 1.
January 1987, Annales de recherches veterinaires. Annals of veterinary research,
R Fensterbank, and P Pardon, and J Marly
Comparison of the efficacy of Brucella abortus strain RB51 and Brucella melitensis Rev. 1 live vaccines against experimental infection with Brucella melitensis in pregnant ewes.
December 2001, Revue scientifique et technique (International Office of Epizootics),
R Fensterbank, and P Pardon, and J Marly
Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes.
February 1995, Vaccine,
R Fensterbank, and P Pardon, and J Marly
Immunopathological responses and kinetics of Brucella melitensis Rev 1 infection after subcutaneous or conjunctival vaccination in rams.
May 2008, Vaccine,
R Fensterbank, and P Pardon, and J Marly
Conjunctival vaccination of pregnant ewes and goats with Brucella melitensis Rev 1 vaccine: safety and serological responses.
January 1992, Annales de recherches veterinaires. Annals of veterinary research,
R Fensterbank, and P Pardon, and J Marly
Immunization with Brucella melitensis Rev 1 against Brucella ovis infection of rams.
September 1987, Veterinary microbiology,
R Fensterbank, and P Pardon, and J Marly
[Immunization of ewes and she-goats against experimental Brucella melitensis infection. A comparison of REV 1 and H 38 vaccines].
January 1984, Developments in biological standardization,
R Fensterbank, and P Pardon, and J Marly
An ELISA with Brucella lipopolysaccharide antigen for the diagnosis of B. melitensis infection in sheep and for the evaluation of serological responses following subcutaneous or conjunctival B. melitensis strain Rev 1 vaccination.
February 1992, Veterinary microbiology,
R Fensterbank, and P Pardon, and J Marly
Comparison of subcutaneous and conjunctival routes of Rev 1 vaccination for the prophylaxis of Brucella ovis infection in rams.
March 1990, Research in veterinary science,
R Fensterbank, and P Pardon, and J Marly
Protection of rams against Brucella ovis infection by Brucella melitensis Rev. 1 vaccine.
January 1981, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,
Copied contents to your clipboard!