-transparent.png){kind=logo}
Three commercial formulations of 2,2,2-trifluoroethanol (TFE) were applied to eyes of rabbits and evaluated for their potential to cause ocular damage. All three products were severe eye irritants and water irrigation shortly after exposure was not effective in reducing ocular damage. Gross and histological observations revealed marked conjunctivitis, moderate to severe ulcerative keratitis, and hyperemia and edema of the iris, all of which showed evidence of resolution over the three-week course of investigation. However, complete reversal of all effects was not attained. TFE and its commercial formulations should be viewed as potentially severe human ocular irritants.
Related Publications
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
July 1969,
Toxicology and applied pharmacology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
January 1988,
Toxicologic pathology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
January 1987,
Toxicologic pathology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
June 1986,
Toxicology and applied pharmacology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
November 1992,
Biochemical pharmacology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
June 1987,
Toxicology and applied pharmacology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
January 1988,
Critical reviews in toxicology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
November 2009,
Magnetic resonance in chemistry : MRC,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
October 1983,
Toxicology and applied pharmacology,
T C Marshall, and
F F Hahn, and
B S Merickel, and
C H Hobbs
June 1988,
Toxicology and applied pharmacology,
