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The newly synthesized 2-[203Hg]-estradiol-17 beta and 4-[203Hg]-estradiol-17 beta were injected into Fischer female rats bearing transplanted mammary adenocarcinomas and into Sprague-Dawley female rats bearing spontaneous mammary tumors. Four days after injection, tumor to blood ratios (and uterine to blood ratios) in the various groups were between 5 and 14, compared to a ratio of unity observed in normal mammary glands. When injected into male rats, the accumulation of 4-[203Hg]-estradiol in the prostate and in the epididimis was very low. With minute doses of 4-[203Hg]-estradiol injected into healthy male rats, the whole-body retention of the drug was found to decrease exponentially with time, and biphasic first order kinetics were observed. With pharmacological doses of the same drug, the clearance exhibited a biphasic pattern.
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
October 1964,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
April 1981,
Cancer research,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
January 2020,
Photochemistry and photobiology,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
September 1978,
Experientia,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
January 1979,
International journal of nuclear medicine and biology,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
January 1975,
Drug metabolism and disposition: the biological fate of chemicals,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
July 1987,
Journal of pharmacobio-dynamics,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
October 1988,
Chemical & pharmaceutical bulletin,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
October 1978,
Gan,
J Shani, and
L M Lieberman, and
A Samuni, and
T Schlesinger, and
M Cais
April 1999,
International journal of experimental pathology,
