Biomaterial Database

Granulocyte factors as potential haemopoiesis regulators in irradiated mice. 1982

Z Sułowska, and H Tchórzewski, and B Wojdalska

Protein substances stimulating lymphocytes in vivo and in vitro are present in the lysosomes and secondary granules of neutrophil granulocytes. The mechanism of this stimulation is probably dependent on blockade of T suppressor cell functions. These observations stimulated the present study undertaken to clarify the effect of granulocyte factors on the multipotential stem cells of the haemopoietic system in mice subjected to sublethal irradiation. The experiments were carried out on F1 hybrid (Balb/cx NMRI) mice receiving a whole body dose of 3 Gy irradiation. Granulocyte proteins were injected intravenously in doses of 6 micrograms per one mouse 18, 48 and 72 hours after irradiation. The assayed proteins increased the number of macroscopic and microscopic colony forming cells in the mice spleens. The increase of erythrocyte granulocyte index in colonies and decrease of lymphocyte granulocyte index in peripheral blood have been observed. In the light of these results it is concluded that lysosomal granules and secondary granules of neutrophils contain protein factors stimulating the regeneration of haemopoietic cells of the erythrocyte and granulocyte series in the irradiated mice spleens.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D011827	Radiation	Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).	Radiations
D002457	Cell Extracts	Preparations of cell constituents or subcellular materials, isolates, or substances.	Cell Extract,Extract, Cell,Extracts, Cell
D005260	Female		Females
D006098	Granulocytes	Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.	Granulocyte
D006410	Hematopoiesis	The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).	Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006412	Hematopoietic Stem Cells	Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.	Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia