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Budipine, a new potential antiparkinsonian drug, did not affect or--in higher doses--inhibited the flexor reflex in spinal rats, having no influence on LSD- or fenfluramine-induced flexor-reflex stimulation. It did not affect the body temperature either of the rat kept at a high ambient temperature or of the rabbit in a normothermic surroundings. It weakened fenfluramine hyperthermia in heat-adapted rats, but not in rabbits. Only in high doses budipine weakened tryptamine-induced clonic convulsions of rat forepaws. Budipine partially prevented fenfluramine-induced depletion of whole brain 5-hydroxytryptamine. The above results show that budipine demonstrates some properties of 5-HT uptake inhibitors.
E Przegaliński, and
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A Lewandowska
August 1990,
Cephalalgia : an international journal of headache,
E Przegaliński, and
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A Lewandowska
September 1981,
Pharmacopsychiatria,
E Przegaliński, and
K Bigajska, and
A Lewandowska
March 1983,
Activitas nervosa superior,
E Przegaliński, and
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A Lewandowska
May 2022,
Pharmaceuticals (Basel, Switzerland),
E Przegaliński, and
K Bigajska, and
A Lewandowska
April 1996,
European journal of pharmacology,
E Przegaliński, and
K Bigajska, and
A Lewandowska
February 1993,
The Journal of pharmacology and experimental therapeutics,
E Przegaliński, and
K Bigajska, and
A Lewandowska
November 1976,
Bollettino della Societa italiana di biologia sperimentale,
E Przegaliński, and
K Bigajska, and
A Lewandowska
December 1991,
European journal of pharmacology,
E Przegaliński, and
K Bigajska, and
A Lewandowska
January 1991,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
E Przegaliński, and
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February 1985,
Neuroendocrinology,
