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The so-called beta conformer of dopamine has been proposed to be involved in agonist--receptor interactions at several sites in the dopaminergic nervous system. Further to evaluate this proposal, rigid congeners of the beta conformer derived from linearly and angularly annelated octahydrobenzoquinolines have been synthesized. Certain N-alkylated trans-angularly annelated systems exhibited unusually potent and highly selective dopamine-like effects in an assay on a cardioaccelerator nerve preparation in the cat, but these compounds were inactive in a variety of assays for CNS effects. These compounds present a clear separation of CNS effects from some potent peripheral effects.
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
February 1984,
Journal of medicinal chemistry,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
August 1976,
Journal of medicinal chemistry,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
July 1986,
Naunyn-Schmiedeberg's archives of pharmacology,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
November 1984,
The Journal of pharmacology and experimental therapeutics,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
June 1985,
Journal of pharmaceutical sciences,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
January 1988,
Molecular pharmacology,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
December 1964,
Chemical & pharmaceutical bulletin,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
November 1978,
Journal of pharmaceutical sciences,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
April 1968,
Chemical & pharmaceutical bulletin,
J G Cannon, and
T Lee, and
H D Goldman, and
J P Long, and
J R Flynn, and
T Verimer, and
B Costall, and
R J Naylor
April 2001,
Bioorganic & medicinal chemistry letters,
